Periodic fasting starves cisplatin-resistant cancers to death

Treatment of cancers with the cytotoxic agent cisplatin frequently evokes resis-tance, accompanied by rewiring of meta-bolic pathways, limiting its clinical use.

Recent research by Obrist et al (2018) shows that cisplatin-resistant growth of lung adenocarcinoma is particularly vulnerable to periodic fasting cycles and starvation-induced cell death, due to its dependency on glutamine, required for nucleoside biosynthesis, suggesting an opportunity for nutritional anti-cancer interventions.

Novella Guidi & Valter D Longo, The EMBO Journal 37:e99815 | 2018